Margot voices one of the Storytellers in A Single Woman She got her first acting job, in the Norman Jewison film Gaily, Gaily (1969). This led to another starring role in Quackser Fortune Has a Cousin in the Bronx (1970), in which she co-starred with Gene Wilder. After some time in New York, studying acting she returned to Hollywood. She met actress Jennifer Salt at a screen test, resulting in a friendship that still stands strong today. Margot and Jennifer moved into a lofty beach house and befriended other, then unknown, struggling filmmakers such as Martin Scorsese, Brian De Palma, Steven Spielberg and Susan Sarandon, among others. Late nights would see the hot, happening youngsters up until all hours talking around a fire about how they were all going to change the film industry. It was crazy living and within the Christmas season, Margot had become involved with De Palma, and as a Christmas present he gave her the script to his upcoming film Sisters (1973). Margot and Salt both had the leads in the film, and it was a huge critical success. The film made branded Margot as a major talent, and in the following years she starred in a string of critically acclaimed pictures, such as Black Christmas (1974), The Great Waldo Pepper (1975), 92 in the Shade (1975) - directed by Thomas McGuane, who was also her husband for a brief period - and a somewhat prophetic tale of self-resurrection, The Reincarnation of Peter Proud (1975). After three years of being a housewife, looking after her daughter Maggie and not working, Margot decided it was time to let her emotions take control and get back into acting. Once her marriage to McGuane was over she eyed a script that would change her life forever. Her new agent hooked her up with a little-known director named Richard Donner. He was going to be directing a film called Superman (1978), and she auditioned for and secured the leading female role of Lois Lane. That film and Superman II (1980) were to be filmed simultaneously. After the success of "Superman" she took on more intense roles, such as The Amityville Horror (1979) and Willie and Phil (1980). After that, Margot did numerous films, television and theater work throughout the 1980s, including Superman IV: The Quest for Peace (1987). When the 1990s erupted with the Gulf War, Margot found herself becoming involved in politics. She made a stir in the biz when she spoke out against the military for their actions in Kuwait. She also appeared in a cameo in Donner's Maverick (1994). After a public struggle in 1996 with her mental health, Margot got back on her feet and started the mental wellness campaign. Since then she has sustained her career in film, television, and theater, recently appearing in a Canadian stage production of The Vagina Monologues.